|
Symbol Name ID |
Icos
inducible T cell co-stimulator MGI:1858745 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Secretory IgA deficiency |
Impaired T cell function |
Neutropenia in presence of anti-neutropil antibodies |
Decreased proportion of class-switched memory B cells |
B lymphocytopenia |
Abnormal T cell count |
Abnormal lymphocyte morphology |
Recurrent sinusitis |
Conjunctivitis |
Lymphadenopathy |
Splenomegaly |
Recurrent infection of the gastrointestinal tract |
Recurrent otitis media |
Chronic intestinal candidiasis |
Pneumonia |
Recurrent pneumonia |
Autoimmunity |
Immunodeficiency |
Recurrent infections |
Recurrent bacterial infections |
Recurrent respiratory infections |
Recurrent bronchitis |
Recurrent sinopulmonary infections |
| Disease(s) Associated with ICOS | ||||||||||||||||||||||||||
| common variable immunodeficiency 1 | ||||||||||||||||||||||||||
| immunoglobulin alpha deficiency |
| Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
insulitis |
abnormal B cell selection |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal leukocyte cell number |
abnormal B cell number |
decreased germinal center B cell number |
decreased plasma cell number |
increased plasma cell number |
abnormal memory B cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased T cell number |
abnormal spleen morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG2c level |
increased IgG3 level |
decreased IgG level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 2 physiology |
decreased circulating interferon-gamma level |
decreased circulating interleukin-4 level |
abnormal interferon level |
abnormal interleukin level |
abnormal Peyer's patch germinal center morphology |
small Peyer's patches |
small lymph nodes |
abnormal immune system physiology |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
abnormal interleukin secretion |
decreased interleukin-21 secretion |
decreased interleukin-4 secretion |
decreased interleukin-5 secretion |
decreased susceptibility to autoimmune diabetes |
increased susceptibility to experimental autoimmune encephalomyelitis |
decreased autoantibody level |
decreased anti-insulin autoantibody level |
abnormal response to infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1.1Wks/Icostm1.1Wks | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Dgry/Icostm1Dgry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Flv/Icostm1Flv | * | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Mak/Icostm1Mak | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Shr/Icostm1Shr | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Tkan/Icostm1Tkan | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Icostm1Flv/Icos+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools